Year 1516 (MDXVI) was a leap year starting on Tuesday (link will display the full calendar) of the Julian calendar. Events of 1516 January - June March - With the death of Ferdinand II of Aragon, his grandson Charles of Ghent becomes King of Spain as Carlos I. April 23 - The Reinheitsgebot is instituted in Ingolstadt, Bavaria, regulating the purity of beer permissible for sale. July - December July - Selim I of the Ottoman Empire declares war on the Mameluks and invades Syria. Augus… (More on 1516)